Ontology highlight
ABSTRACT:
SUBMITTER: Oldstone MBA
PROVIDER: S-EPMC6099862 | biostudies-other | 2018 Aug
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 20180730 33
Understanding of T cell exhaustion and successful therapy to restore T cell function was first described using Clone (Cl) 13 variant selected from the lymphocytic choriomeningitis virus (LCMV) Armstrong (ARM) 53b parental strain. T cell exhaustion plays a pivotal role in both persistent infections and cancers of mice and humans. C57BL/6, BALB, SWR/J, A/J, 129, C3H, and all but one collaborative cross (CC) mouse strain following Cl 13 infection have immunosuppressed T cell responses, high PD-1, a ...[more]