Ontology highlight
ABSTRACT:
SUBMITTER: Lin L
PROVIDER: S-EPMC6127344 | biostudies-other | 2018 Sep
REPOSITORIES: biostudies-other
Oncogenesis 20180907 9
Mutations in BRAF are common to many cancers, including CRC. The MEK inhibitors are being investigated in BRAF-mutant CRC. In this study, we aimed to investigate how MEK inhibitor suppresses growth of BRAF-mutated CRC cells as well as its potential mechanisms. Our findings indicated that MEK inhibitor promote PUMA expression via ERK/FoxO3a signaling pathway. In addition, PUMA induction is essential for MEK inhibitor-induced apoptosis. Moreover, PUMA induction is required for MEK inhibitors to in ...[more]