Ontology highlight
ABSTRACT:
SUBMITTER: Zamponi E
PROVIDER: S-EPMC6156351 | biostudies-other | 2018 Oct
REPOSITORIES: biostudies-other
Aging cell 20180720 5
Mounting evidence implicates chronic oxidative stress as a critical driver of the aging process. Down syndrome (DS) is characterized by a complex phenotype, including early senescence. DS cells display increased levels of reactive oxygen species (ROS) and mitochondrial structural and metabolic dysfunction, which are counterbalanced by sustained Nrf2-mediated transcription of cellular antioxidant response elements (ARE). Here, we show that caspase 3/PKCδdependent activation of the Nrf2 pathway in ...[more]