Ontology highlight
ABSTRACT:
SUBMITTER: Gonzalez-Garcia I
PROVIDER: S-EPMC6198289 | biostudies-other | 2018 Oct
REPOSITORIES: biostudies-other
Cell reports 20181001 2
Compelling evidence has shown that, besides its putative effect on the regulation of the gonadal axis, estradiol (E2) exerts a dichotomic effect on the hypothalamus to regulate food intake and energy expenditure. The anorectic effect of E2 is mainly mediated by its action on the arcuate nucleus (ARC), whereas its effects on brown adipose tissue (BAT) thermogenesis occur in the ventromedial nucleus (VMH). Here, we demonstrate that central E2 decreases hypothalamic ceramide levels and endoplasmic ...[more]