Ontology highlight
ABSTRACT:
SUBMITTER: Wallmann T
PROVIDER: S-EPMC6214839 | biostudies-other | 2018 Oct
REPOSITORIES: biostudies-other
iScience 20181016
High-grade gliomas (HGGs) are the most aggressive and invasive primary brain tumors. The platelet-derived growth factor (PDGF) signaling pathway drives HGG progression, and enhanced expression of PDGF receptors (PDGFRs) is a well-established aberration in a subset of glioblastomas (GBMs). PDGFRA is expressed in glioma cells, whereas PDGFRB is mostly restricted to the glioma-associated stroma. Here we show that the spatial location of TAMMs correlates with the expansion of a subset of tumor cells ...[more]