Circulating natural antibodies to inflammatory cytokines are potential biomarkers for atherosclerosis.

ABSTRACT: Background:Inflammatory cytokines contribute to the development of atherosclerosis. Natural antibodies in the circulation have protective effects on common diseases including atherosclerosis-related conditions. Purpose:The present study aimed to investigate the possible involvement of circulating IgG antibodies against inflammatory cytokines in atherosclerosis. Methods:A total of 220 patients with diagnosis of atherosclerosis and 200 healthy controls were recruited. Seven linear peptide antigens were used to develop an enzyme-linked immunosorbent assay in-house for detection of plasma IgG antibodies against interleukin 1? (fragments IL1?-1 and IL1?-2), IL6, IL8, tumor necrosis factor alpha (fragments TNF?-1 and TNF?-2) and IL1?. Results:Atherosclerotic patients had an increase in the levels of circulating IgG to TNF?-1(adjusted r2 = 0.038, p?

SUBMITTER: Wang P 

PROVIDER: S-EPMC6240255 | biostudies-other | 2018

REPOSITORIES: biostudies-other