Oxidative stress markers in tears of patients with Graves' orbitopathy and their correlation with clinical activity score.

ABSTRACT: BACKGROUND:To investigate the concentrations of oxidative stress markers, 8-hydroxy-2'-deoxyquanosine (8-OHdG) and malondialdehyde (MDA), in tears and their correlation with the clinical activity score (CAS) in patients with Graves' orbitopathy (GO) according to disease activity. METHODS:We recruited 27 participants with inactive stage GO, 35 participants with active stage GO, and 25 healthy controls without GO. The tear concentrations of 8-OHdG and MDA were determined by enzyme-linked immunosorbent assay. The correlation between CAS and the concentrations of tear 8-OHdG and MDA were analyzed according to the disease activity in the GO patients. RESULTS:The levels of 8-OHdG and MDA were 56.30?±?16.81?ng/mL and 5.39?±?1.31?pmol/mg, respectively, in the control subjects, and 123.46?±?22.67?ng/mL and 13.59?±?3.93?pmol/mg, respectively, in patients with inactive stage GO, and 215.14?±?35.61?ng/mL and 22.52?±?4.63?pmol/mg, in patients with active stage GO. The mean concentrations of 8-OHdG and MDA were higher in patients with inactive and active stage GO compared with the control group (all P?

SUBMITTER: Choi W 

PROVIDER: S-EPMC6249971 | biostudies-other | 2018 Nov

REPOSITORIES: biostudies-other