Ontology highlight
ABSTRACT:
SUBMITTER: Mizuno TM
PROVIDER: S-EPMC6266206 | biostudies-other | 2018 Nov
REPOSITORIES: biostudies-other
Nutrients 20181101 11
Common genetic variants of the fat mass and obesity associated (<i>FTO</i>) gene are strongly associated with obesity and type 2 diabetes. FTO is ubiquitously expressed. Earlier studies have focused on the role of hypothalamic FTO in the regulation of metabolism. However, recent studies suggest that expression of hepatic FTO is regulated by metabolic signals, such as nutrients and hormones, and altered FTO levels in the liver affect glucose and lipid metabolism. This review outlines recent findi ...[more]