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Uncarilic acid and secouncarilic acid, two new triterpenoids from Uucaria sessilifructus.

ABSTRACT: Two new compounds, the 6-oxo oleanane-type triterpenoid uncarilic acid, and its 5,6-secotriterpenoid derivative, secouncarilic acid, were isolated from the hooks and stems of Uucaria sessilifructus together with seven known ursane-type triterpenoids. Uncarilic acid is the second 6-oxo oleanane-type triterpenoid ever reported, while secouncarilic acid is the first oleanane-type 5,6-secotriterpenoid. A plausible biosynthetic pathway from uncarilic acid to secouncarilic acid was also postulated. The inhibitory activities of all the nine compounds against LPS-induced nitric oxide production in RAW264.7 macrophages were evaluated.

SUBMITTER: Zhang MJ

PROVIDER: S-EPMC6270339 | biostudies-other | 2013

REPOSITORIES: biostudies-other

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Uncarilic acid and secouncarilic acid, two new triterpenoids from Uucaria sessilifructus.

Zhang Mao-Juan MJ Liu Bing B Liao Shang-Gao SG Xu You-Kai YK Feng De-Qiang DQ Ji Kai-Long KL Li Yan Y

Molecules (Basel, Switzerland) 20130814 8

Two new compounds, the 6-oxo oleanane-type triterpenoid uncarilic acid, and its 5,6-secotriterpenoid derivative, secouncarilic acid, were isolated from the hooks and stems of Uucaria sessilifructus together with seven known ursane-type triterpenoids. Uncarilic acid is the second 6-oxo oleanane-type triterpenoid ever reported, while secouncarilic acid is the first oleanane-type 5,6-secotriterpenoid. A plausible biosynthetic pathway from uncarilic acid to secouncarilic acid was also postulated. Th ...[more]

PMID: 23948713

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