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Two new guaiane sesquiterpenoids from Daphne holosericea (Diels) Hamaya.


ABSTRACT: Two new sesquiterpenoids with guaiane skeletons-holosericin A (1) and holosericin B (2)-were isolated from the medicinal plant Daphne holosericea (Diels) Hamawa (Thymelaeceae). Their structures were elucidated by 1D and 2D-NMR spectroscopy, as well as HR-ESI-MS data. Compounds 1 and 2 were evaluated for inhibitory activities against acetylcholinesterase and compound 2 showed a moderate activity with 31% inhibition.

SUBMITTER: Ma QY 

PROVIDER: S-EPMC6271883 | biostudies-other | 2014

REPOSITORIES: biostudies-other

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Two new guaiane sesquiterpenoids from Daphne holosericea (Diels) Hamaya.

Ma Qing-Yun QY   Chen Yi-Chun YC   Huang Sheng-Zhuo SZ   Guo Zhi-Kai ZK   Dai Hao-Fu HF   Hua Yan Y   Zhao You-Xing YX  

Molecules (Basel, Switzerland) 20140911 9


Two new sesquiterpenoids with guaiane skeletons-holosericin A (1) and holosericin B (2)-were isolated from the medicinal plant Daphne holosericea (Diels) Hamawa (Thymelaeceae). Their structures were elucidated by 1D and 2D-NMR spectroscopy, as well as HR-ESI-MS data. Compounds 1 and 2 were evaluated for inhibitory activities against acetylcholinesterase and compound 2 showed a moderate activity with 31% inhibition. ...[more]

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