Ontology highlight
ABSTRACT:
SUBMITTER: Mair G
PROVIDER: S-EPMC6282236 | biostudies-other | 2018 Nov
REPOSITORIES: biostudies-other
Neurology 20181026 22
<h4>Objective</h4>To determine whether alteplase alters the development of ischemic lesions on brain imaging after stroke.<h4>Methods</h4>The Third International Stroke Trial (IST-3) was a randomized controlled trial of IV alteplase for ischemic stroke. We assessed CT or brain MRI at baseline (pretreatment) and 24 to 48 hours posttreatment for acute lesion visibility, extent, and swelling, masked to all other data. We analyzed associations between treatment allocation, change in brain tissue app ...[more]