Ontology highlight
ABSTRACT:
SUBMITTER: Ferrari SM
PROVIDER: S-EPMC6305332 | biostudies-other | 2018
REPOSITORIES: biostudies-other
Ferrari Silvia Martina SM La Motta Concettina C Elia Giusy G Ragusa Francesca F Ruffilli Ilaria I Quattrini Luca L Paparo Sabrina Rosaria SR Piaggi Simona S Patrizio Armando A Ulisse Salvatore S Baldini Enke E Materazzi Gabriele G Fallahi Poupak P Antonelli Alessandro A
Frontiers in endocrinology 20181218
Anaplastic thyroid carcinoma (ATC) is a malignant tumor of the thyroid gland, infrequent but with a very poor prognosis, as it rapidly causes death (mean survival of about 6 months). ATC treatment includes a multimodal protocol consisting of surgery, chemotherapy (doxorubicin and cisplatin), and hyperfractionated accelerated external beam radiotherapy (median patient survival of 10 months). For this reason, the identification of an effective systemic treatment for ATC would be a major advance in ...[more]