Unknown

Dataset Information

0

Heat-Killed Saccharomyces cerevisiae, A Dectin-1 Agonist, Selectively Induces IgG4 Production by Human B Cells.

ABSTRACT: Dectin-1 is a major receptor that recognizes fungal cell wall ?-glucan. We previously reported that heat-killed Saccharomyces cerevisiae (HKSC), a Dectin-1 agonist, selectively induces IgG1 class switching in mouse B cells. Dectin-1 is also expressed on human B cells; however, Dectin-1 function in human B cells remains unknown. This study aimed to investigate the direct effect of in vitro stimulation using HKSC on Ig class switching in human B cells. HKSC selectively induced the expression of germline ?4 transcripts (GLT?4) by human B cell line 2E2, and HKSC significantly augmented GLT?4 promoter activity. Moreover, HKSC selectively enhanced GLT?4 expression and IgG4 production by anti-CD40-activated human tonsillar resting B cells. Thus, these results suggest that Dectin-1 maybe involved in selective IgG4 class switching by human B cells.

SUBMITTER: Park HY 

PROVIDER: S-EPMC6312892 | biostudies-other | 2018 Dec

REPOSITORIES: biostudies-other

Json Xml
altmetric image

Publications

Heat-Killed <i>Saccharomyces cerevisiae</i>, A Dectin-1 Agonist, Selectively Induces IgG4 Production by Human B Cells.

Park Ha-Yan HY   Yoon Hee-Kyung HK   Kim Jong-Yeup JY   Park Seok-Rae SR  

Immune network 20181220 6

Dectin-1 is a major receptor that recognizes fungal cell wall β-glucan. We previously reported that heat-killed <i>Saccharomyces cerevisiae</i> (HKSC), a Dectin-1 agonist, selectively induces IgG1 class switching in mouse B cells. Dectin-1 is also expressed on human B cells; however, Dectin-1 function in human B cells remains unknown. This study aimed to investigate the direct effect of <i>in vitro</i> stimulation using HKSC on Ig class switching in human B cells. HKSC selectively induced the ex  ...[more]