Ontology highlight
ABSTRACT:
SUBMITTER: Vitiello E
PROVIDER: S-EPMC6318293 | biostudies-other | 2019 Jan
REPOSITORIES: biostudies-other
Nature communications 20190103 1
The presence of aberrant number of centrioles is a recognized cause of aneuploidy and hallmark of cancer. Hence, centriole duplication needs to be tightly regulated. It has been proposed that centriole separation limits centrosome duplication. The mechanism driving centriole separation is poorly understood and little is known on how this is linked to centriole duplication. Here, we propose that actin-generated forces regulate centriole separation. By imposing geometric constraints via micropatte ...[more]