Ontology highlight
ABSTRACT:
SUBMITTER: Osking Z
PROVIDER: S-EPMC6327879 | biostudies-other | 2019 Jan
REPOSITORIES: biostudies-other
iScience 20181227
Amyotrophic lateral sclerosis (ALS) is a progressive, fatal neurodegenerative disease characterized by motor neuron cell death. However, not all motor neurons are equally susceptible. Most of what we know about the surviving motor neurons comes from gene expression profiling; less is known about their functional traits. We found that resistant motor neurons cultured from SOD1 ALS mouse models have enhanced axonal outgrowth and dendritic branching. They also have an increase in the number and siz ...[more]