Ontology highlight
ABSTRACT:
SUBMITTER: Murall CL
PROVIDER: S-EPMC6361466 | biostudies-other | 2019 Jan
REPOSITORIES: biostudies-other
PLoS computational biology 20190123 1
Infections of stratified epithelia contribute to a large group of common diseases, such as dermatological conditions and sexually transmitted diseases. To investigate how epithelial structure affects infection dynamics, we develop a general ecology-inspired model for stratified epithelia. Our model allows us to simulate infections, explore new hypotheses and estimate parameters that are difficult to measure with tissue cell cultures. We focus on two contrasting pathogens: Chlamydia trachomatis a ...[more]