Ontology highlight
ABSTRACT:
SUBMITTER: Kim H
PROVIDER: S-EPMC6377681 | biostudies-other | 2019 Feb
REPOSITORIES: biostudies-other
Nature communications 20190215 1
When developing a synthetic methodology, chemists generally optimize a single substrate and then explore the substrate scope of their method. This approach has led to innumerable and widely-used chemical reactions. However, it frequently provides methods that only work on model substrate-like compounds. Perhaps worse, reaction conditions that would enable the conversion of other substrates may be missed. We now show that a different approach, originally proposed by Kagan, in which a collection o ...[more]