Ontology highlight
ABSTRACT:
SUBMITTER: Hard J
PROVIDER: S-EPMC6444814 | biostudies-other | 2019 Apr
REPOSITORIES: biostudies-other
Genome biology 20190401 1
Accurate variant calling and genotyping represent major limiting factors for downstream applications of single-cell genomics. Here, we report Conbase for the identification of somatic mutations in single-cell DNA sequencing data. Conbase leverages phased read data from multiple samples in a dataset to achieve increased confidence in somatic variant calls and genotype predictions. Comparing the performance of Conbase to three other methods, we find that Conbase performs best in terms of false dis ...[more]