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Perineural Invasion in Head and Neck Cancer.

ABSTRACT: Perineural invasion (PNI) is a mechanism of tumor dissemination that can provide a challenge to tumor eradication and that is correlated with poor survival. Squamous cell carcinoma, the most common type of head and neck cancer, has a high prevalence of PNI. This review provides an overview of clinical studies on the outcomes and factors associated with PNI in head and neck cancer and on findings on cancer-nerve crosstalk.

SUBMITTER: Schmitd LB 

PROVIDER: S-EPMC6728584 | biostudies-other | 2018 Jul

REPOSITORIES: biostudies-other

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Perineural Invasion in Head and Neck Cancer.

Schmitd L B LB   Scanlon C S CS   D'Silva N J NJ  

Journal of dental research 20180214 7

Perineural invasion (PNI) is a mechanism of tumor dissemination that can provide a challenge to tumor eradication and that is correlated with poor survival. Squamous cell carcinoma, the most common type of head and neck cancer, has a high prevalence of PNI. This review provides an overview of clinical studies on the outcomes and factors associated with PNI in head and neck cancer and on findings on cancer-nerve crosstalk. ...[more]