Pan-cancer ion transport signature reveals functional regulators of glioblastoma aggression

ABSTRACT: Ion channels, transporters, and other ion-flux controlling proteins, collectively comprising the "ion permeome", are common drug targets, however their roles in cancer remain understudied. Our integrative pan-cancer transcriptome analysis shows that genes encoding the ion permeome are significantly more often highly expressed in specific subsets of cancer samples, compared to pan-transcriptome expectations. To enable target selection, we identified 410 survival-associated IP genes in 33 cancer types using a machine-learning approach. Notably, GJB2 and SCN9A show prominent expression in neoplastic cells and associate with poor prognosis in glioblastoma, the most common and aggressive brain cancer. GJB2 or SCN9A knockdown in patient-derived glioblastoma cells induces transcriptome-wide chang

SUBMITTER: Alexander, T. Bahcheli 

PROVIDER: S-SCDT-10_1038-S44318-023-00016-X | biostudies-other |

REPOSITORIES: biostudies-other