NINJ1 induces plasma membrane rupture and release of damage-associated molecular pattern molecules during ferroptosis

ABSTRACT: Ferroptosis is a regulated form of necrotic cell death caused by iron-dependent accumulation of oxidized phospholipids in cellular membranes, culminating in plasma membrane rupture (PMR) and cell lysis. Plasma membrane rupture is also a hallmark of other types of programmed necrosis, such as pyroptosis and necroptosis, where it is initiated by dedicated pore-forming cell death-executing factors. However, whether ferroptosis-associated PMR is also actively executed by proteins or driven by osmotic pressure remains unknown. Here, we investigate a potential ferroptosis role of ninjurin-1 (NINJ1), a recently identified executor of pyroptosis-associated PMR. We report that NINJ1 oligomerizes during ferroptosis, and that Ninj1 deficiency protects macrophages and fibroblasts from ferroptosis-asso

SUBMITTER: Ms. Saray Ramos 

PROVIDER: S-SCDT-10_1038-S44318-024-00055-Y | biostudies-other |

REPOSITORIES: biostudies-other