Whole-body replacement of larval myofibers generates permanent adult myofibers in zebrafish

ABSTRACT: Drastic increases in myofiber number and size are essential to support vertebrate post-embryonic growth. However, the collective cellular behaviors that enable these increases have remained elusive. Here, we created the palmuscle myofiber tagging and tracking system for in toto monitoring of the growth and fates of ~5000 fast myofibers in developing zebrafish larvae. Through live tracking of individual myofibers within the same individuals over extended periods, we found that many larval myofibers readily dissolved during development, enabling the on-site addition of new and more myofibers. Remarkably, whole-body surveillance of multicolor-barcoded myofibers further unveiled a gradual yet extensive elimination of larval myofiber populations, resulting in near-total replacement by late juve

SUBMITTER: Dr. Chen-Hui Chen 

PROVIDER: S-SCDT-10_1038-S44318-024-00136-Y | biostudies-other |

REPOSITORIES: biostudies-other