LINE-1 RNA triggers matrix formation in bone cells via a PKR-mediated inflammatory response

ABSTRACT: Transposable elements (TEs) are mobile genetic modules of viral derivation that have been co-opted to become modulators of mammalian gene expression. TEs are a major source of endogenous dsRNAs, signaling molecules able to coordinate inflammatory responses in various physiological processes. Here, we provide evidence for a positive involvement of TEs in inflammation-driven bone repair and mineralization. In newly fractured mice bone, we observed an early transient upregulation of repeats occurring concurrently with the initiation of the inflammatory stage. In human bone biopsies, analysis revealed a significant correlation between repeats expression, mechanical stress and bone mineral density. We investigated a potential link between LINE-1 (L1) expression and bone mineralization by delive

SUBMITTER: Dr. Arianna Mangiavacchi 

PROVIDER: S-SCDT-10_1038-S44318-024-00143-Z | biostudies-other |

REPOSITORIES: biostudies-other