PRC2- EZH1 contributes to circadian gene expression by orchestrating chromatin states and RNA polymerase II complex stability

ABSTRACT: Circadian rhythmicity of gene expression is a conserved feature of cell physiology. This involves fine-tuning between transcriptional and post-transcriptional mechanisms and strongly depends on the metabolic state of the cell. Together these processes guarantee an adaptive plasticity of tissue-specific genetic programs. However, it is unclear how the epigenome and RNA Pol II rhythmicity are integrated. Here we show that the PcG protein EZH1 has a gateway bridging function in post-mitotic skeletal muscle cells. On one hand, the circadian clock master regulator BMAL1 directly controls oscillatory behavior and periodic assembly of core components of the PRC2-EZH1 complex. On the other hand, EZH1 is essential for circadian gene expression at alternate Zeitgeber times, through stabilization of

SUBMITTER: Prof. Valerio Orlando 

PROVIDER: S-SCDT-10_1038-S44318-024-00267-2 | biostudies-other |

REPOSITORIES: biostudies-other