The novel myokine FNDC1 promotes muscle regeneration and alleviates muscular dystrophy

ABSTRACT: Myogenesis is essential for skeletal muscle formation and regeneration after injury, yet its regulators are largely unknown. Here we identified a previously uncharacterized myokine fibronectin type III domain containing 1 (FNDC1). In vitro studies showed that knockdown of Fndc1 in myoblasts reduced myotube formation, while overexpression of Fndc1 promoted myogenic differentiation. We further generated a truncated recombinant mouse FNDC1 (mFNDC1) that retains reliable activity in promoting myoblast differentiation. Gain- and loss-of-function studies collectively showed that FNDC1 promoted cardiotoxin (CTX)-induced muscle regeneration in adult mice. Furthermore, recombinant FNDC1 treatment ameliorated muscle pathological phenotypes in the mdx mouse model of Duchenne muscular dystrophy. Mecha

SUBMITTER: Rui Xin Zhang 

PROVIDER: S-SCDT-10_1038-S44318-024-00285-0 | biostudies-other |

REPOSITORIES: biostudies-other