Elongator is a microtubule polymerase selective for polyglutamylated tubulin

ABSTRACT: Elongator is a tRNA-modifying complex that regulates protein translation. Recently, a moonlighting function of Elongator has been identified in regulating the polarization of the microtubule cytoskeleton during asymmetric cell division. Elongator induces symmetry breaking of the anaphase midzone by selectively stabilizing microtubules on one side of the spindle, contributing to the downstream polarized segregation of cell-fate determinants, and therefore to cell fate determination. Here, we investigate how Elongator controls microtubule dynamics. Elongator binds both to the tip of microtubules and to free GTP-tubulin heterodimers using two different subcomplexes, Elp123 and Elp456, respectively. We show that these activities must be coupled for Elongator to decrease the tubulin critical co

SUBMITTER: Vicente, J Planelles-Herrero 

PROVIDER: S-SCDT-10_1038-S44318-024-00358-0 | biostudies-other |

REPOSITORIES: biostudies-other