Transcriptional landscapes underlying Notch-induced lineage conversion and plasticity of mammary basal cells

ABSTRACT: The mammary epithelium derives from multipotent mammary stem cells (MaSCs) that engage into differentiation during embryonic development. However, adult MaSCs maintain the ability to reactivate multipotency in non-physiological contexts. We previously reported that Notch1 activation in committed basal cells triggers a basal-to-luminal cell fate switch in the mouse mammary gland. Here, we report conservation of this mechanism and found that in addition to the mammary gland, constitutive Notch1 signaling induces a basal-to-luminal cell fate switch in adult cells of the lacrimal gland, the salivary gland, and the prostate. Since the lineage transition is progressive in time, we performed single-cell transcriptomic analysis on index-sorted mammary cells at different stages of lineage conversio

SUBMITTER: Candice Merle 

PROVIDER: S-SCDT-10_1038-S44318-025-00424-1 | biostudies-other |

REPOSITORIES: biostudies-other