Early coordination of cell migration and cardiac fate determination during mammalian gastrulation.

ABSTRACT: During gastrulation, mesodermal cells derived from distinct regions are destined to acquire specific cardiac fates after undergoing complex migratory movements. Here, we used lightsheet imaging of live mouse embryos between gastrulation and heart tube formation to track mesodermal cells and to reconstruct lineage trees and 3D migration paths for up to five cell divisions. We found independent progenitors emerging at specific times, contributing exclusively to left ventricle/atrioventricular canal (LV/AVC) or atrial myocytes. LV/AVC progenitors differentiated early to form the cardiac crescent, while atrial progenitors later generated the heart tube's inflow tract during morphogenesis. We also identified short-lived multi-potent progenitors with broad potential, illustrating early developme

SUBMITTER: Shayma Abukar 

PROVIDER: S-SCDT-10_1038-S44318-025-00441-0 | biostudies-other |

REPOSITORIES: biostudies-other