Landscape of the Epstein-Barr virus-host chromatin interactome and gene regulation

ABSTRACT: The three-dimensional (3D) chromatin structure of Epstein-Barr Virus (EBV) within host cells and the underlying mechanisms of chromatin interaction and gene regulation, particularly those involving EBV's non-coding RNAs (ncRNAs), have remained incompletely characterized. In this study, we employed state-of-the-art techniques of 3D genome mapping, including protein-associated chromatin-interaction analysis with paired-end tag sequencing (ChIA-PET), RNA-associated chromatin interaction technique (RDD), and super-resolution microscopy, to delineate the spatial architecture of EBV in human lymphoblastoid cells. We systematically analyzed EBV-to-EBV (E-E), EBV-to-host (E-H), and host-to-host (H-H) interactions linked to host proteins and EBV RNAs. Our findings reveal that EBV utilizes host CCCT

SUBMITTER: Meizhen Zheng 

PROVIDER: S-SCDT-10_1038-S44318-025-00466-5 | biostudies-other |

REPOSITORIES: biostudies-other