CGAS-STING are responsible for premature aging of telomerase-deficient zebrafish

ABSTRACT: Telomere shortening occurs in multiple tissues throughout aging. When telomeres become critically short, they trigger DNA-damage responses and p53 stabilization, leading to apoptosis or replicative senescence. In vitro, cells with short telomeres activate the cGAS-STING innate immune pathway resulting in type-I interferon-based inflammation and senescence. However, the consequences of these events for the organism are not yet understood. Here, we show that sting is responsible for premature aging of telomerase-deficient zebrafish. We generated sting-/- tert-/- double-mutant animals and observed a thorough rescue of tert-/- phenotypes. At the cellular level, lack of cGAS-STING in tert mutants resulted in reduced senescence, increased cell proliferation, and decreased inflammation despite si

SUBMITTER: Naz Şerifoğlu 

PROVIDER: S-SCDT-10_1038-S44318-025-00482-5 | biostudies-other |

REPOSITORIES: biostudies-other