Optochemical profiling of NMDAR molecular diversity at synaptic and extrasynaptic sites

ABSTRACT: Neurotransmitter receptors are critical for neuronal communication. They often form large multimeric complexes that differ in their subunit composition, distribution, and signaling properties. N‐methyl‐D‐aspartate receptors (NMDARs), a class of glutamate-gated ion channels with essential roles in brain development and plasticity, co-exist as multiple subtypes, with GluN2A diheteromers, GluN2B diheteromers, and GluN2A/GluN2B triheteromers prevailing in the adult forebrain. Studying individual subtypes in native tissues with subunit stoichiometry resolution remains challenging, and the relative abundance and subcellular distribution of these subtypes remain controversial. Here we use the newly developed photochemical method Opto2B for specific and reversible modulation of GluN2B diheteromers

SUBMITTER: Antoine Sicard 

PROVIDER: S-SCDT-10_1038-S44318-025-00498-X | biostudies-other |

REPOSITORIES: biostudies-other