Proteomic aging signatures across mouse organs and life stages

ABSTRACT: Aging is associated with the accumulation of molecular damage, functional decline, increasing disease prevalence, and ultimately mortality. Although our system-wide understanding of aging has significantly progressed at the genomic and transcriptomic levels, the availability of large-scale proteomic datasets remains limited. To address this gap, we have conducted an unbiased quantitative proteomic analysis in male C57BL/6J mice, examining eight key organs (brain, heart, lung, liver, kidney, spleen, skeletal muscle, and testis) across six life stages (3, 5, 8, 14, 20, and 26-month-old animals). Our results reveal age-associated organ-specific as well as systemic proteomic alterations, with the earliest and most extensive changes observed in kidney and spleen followed by liver and lung, whil

SUBMITTER: Enzo Scifo 

PROVIDER: S-SCDT-10_1038-S44318-025-00509-X | biostudies-other |

REPOSITORIES: biostudies-other