Specific and redundant roles for Gli2 and Gli3 in establishing cell fate during murine hair follicle development

ABSTRACT: Formation of skin epithelial appendages like hair follicles requires hedgehog (Hh) signal reception, its conduction through the primary cilium and activation of Gli transcription factors. How Hh signalling induces cell-type-specific responses through Gli transcription factors in hair follicle stem cells and their cilia-dependence remains unclear. Here, we use conditional mouse mutants to genetically dissect the roles of Gli2 and Gli3 transcription factors and cilia in the skin epithelium. Upon keratinocyte-specific depletion of Gli2, hair follicle morphogenesis is delayed whereas sebaceous gland formation is enhanced, suggesting a dual role for Gli2 during appendage development. Gli2 promotes proliferation of sebaceous gland stem cells, impacting the number and size of individual sebaceous

SUBMITTER: Catherin Niemann 

PROVIDER: S-SCDT-10_1038-S44318-025-00519-9 | biostudies-other |

REPOSITORIES: biostudies-other