NANOG is repurposed after implantation to repress Sox2 and begin pluripotency extinction

ABSTRACT: Loss of pluripotency is an essential step in postimplantation development that facilitates the emergence of somatic cell identities essential for gastrulation. Before implantation, pluripotent cell identity is governed by a gene regulatory network that includes the key transcription factors SOX2 and NANOG. However, it is unclear how the pluripotency gene regulatory network is dissolved to enable lineage restriction. Here, we show that SOX2 is required for post-implantation pluripotent identity in the mouse, and cells that lose SOX2 expression in the posterior epiblast are no longer pluripotent. Using in vitro and in vivo analyses we demonstrate anticorrelated expression of NANOG and SOX2 preceding gastrulation, culminating in an early disappearance of pluripotent identity from posterior NA

SUBMITTER: Frederick, CK Wong 

PROVIDER: S-SCDT-10_1038-S44318-025-00527-9 | biostudies-other |

REPOSITORIES: biostudies-other