Programmed cell revival from imminent cell death enhances tissue repair and regeneration

ABSTRACT: Cell recovery from near-death states is a critical yet poorly understood aspect of cell biology. Here, we describe a tightly-regulated programmed cell revival process after exposure of cells to cell death-inducing lysosomotropic agents, such as L-leucyl-L-leucine methyl ester (LLOMe). In the initial stage of cell recovery, we observe increased chromatin accessibility and upregulation of genes and pathways associated with embryonic development, regeneration, stemness, and inflammation. Subsequently, vital pathways governing metabolism, organelle biogenesis, membrane trafficking, transport, and cytoskeleton remodeling are activated, resulting in the complete renewal of cells. Consistent with the links of this transcriptional profile to tissue repair and regeneration, we found LLOMe to enhanc

SUBMITTER: Kollori Dhar 

PROVIDER: S-SCDT-10_1038-S44318-025-00540-Y | biostudies-other |

REPOSITORIES: biostudies-other