Direct and indirect neurogenesis from radial glial progenitor cell clones in the mouse neocortex

ABSTRACT: The size and complexity of the neocortex are largely determined during brain development by neurogenesis from radial glial progenitor (RGP) cells. Neurogenesis from such cells can be direct (i.e., RGP cells give rise directly to neurons) or indirect (i.e., RGP cells first produce intermediate progenitor cells, which then divide further to produce neurons). How direct and indirect neurogenesis from RGP cells leads to the appropriate neocortical size and cell-type composition remains incompletely understood. In this study, we developed a combined retrovirus- and FlashTag-based labeling technique that allows clonal tracking of sequential RGP divisions and identification of progeny identities in vivo. Using this method, we show that divisions of mouse RGP cells giving rise to neurogenic (N), n

SUBMITTER: Dan Shen 

PROVIDER: S-SCDT-10_1038-S44318-025-00624-9 | biostudies-other |

REPOSITORIES: biostudies-other