Cellular quiescence uncouples the proteome from the transcriptome in neural stem cells

ABSTRACT: Quiescence is a cellular state defined by reversible cell-cycle arrest and diminished biosynthesis, particularly of nucleic acids and proteins. These features protect stem cells from proliferation-induced mutations, self-renewal exhaustion, and environmental insults. Despite relevance to development, tissue homeostasis and cancer, we lack understanding about many aspects of quiescence regulation, and unique molecular markers for this state. Here, we employ Drosophila and mammalian neural stem cells to reveal that a mechanism for inhibiting translation in quiescence is selective nuclear enrichment of transcripts from more than 2,000 genes, resulting in uncoupling between transcriptome and proteome. Three-quarters of these transcripts become increasingly nuclear as quiescence deepens, and nu

SUBMITTER: Alice Rossi 

PROVIDER: S-SCDT-10_1038-S44318-026-00693-4 | biostudies-other |

REPOSITORIES: biostudies-other