Plakoglobin transmits tension across VE-cadherin for vascular leak formation and leukocyte diapedesis

ABSTRACT: VE-cadherin controls endothelial junction integrity, and thereby inflammation-induced vascular permeability and leukocyte extravasation. The adhesive function of VE-cadherin is influenced by its binding to β-catenin, which is linked by β-catenin to actin. Plakoglobin can replace β-catenin in such complexes, and both types of complexes co-exist in endothelial cells. Here, we have investigated whether β-catenin and plakoglobin differ in their relevance for controlling endothelial junctions. Based on gene silencing in vitro and conditional endothelium-specific gene inactivation in mice in vivo, we found that both leukocyte diapedesis through endothelium and induction of vascular permeability by inflammatory mediators depend on plakoglobin, but not β-catenin. Mechanistically, we demonstrated t

SUBMITTER: Neha Uttekar 

PROVIDER: S-SCDT-10_1038-S44318-026-00732-0 | biostudies-other |

REPOSITORIES: biostudies-other