Tissue-selective COPII modulator SEC16B aggravates cardiovascular disease by promoting lipid export

ABSTRACT: The biogenesis and transport of lipoproteins are essential for systemic homeostasis and cardio-metabolic health, yet how the secretory pathway acquires specialization to support high-capacity lipoprotein export remains unclear. Here, we report SEC16B as a tissue-selective modulator of the COPII machinery, critical for the efficient secretion of APOB-containing lipoproteins. Integrative bioinformatic analyses identify that SEC16B co-emerges with core genes involved in lipoprotein biogenesis. Functional studies, coupled with AI-driven prediction, reveal that SEC16B acts as a molecular brake to fine-tune COPII condensation for lipoprotein export. Mining of UK biobank data links SEC16B to metabolic traits in humans and suggests HNF4A-dependent regulation of SEC16B expression. Hepatic deletion

SUBMITTER: Xiao Wang 

PROVIDER: S-SCDT-10_1038-S44318-026-00754-8 | biostudies-other |

REPOSITORIES: biostudies-other