SenSet defines cell-type specific senescence signatures in the aged human lung

ABSTRACT: Cellular senescence is defined as an irreversible growth arrest observed when cells are exposed to a variety of stressors, including DNA damage, oxidative stress, or nutrient deprivation. Although senescence is a well-established driver of aging and age-related diseases, it is a highly heterogeneous process with significant variations across organisms, tissues, and cell types. The relatively low abundance of senescent cells in healthy aged tissues poses a major challenge to the longitudinal study of senescence in specific organs, including the human lung. To overcome this limitation, we developed a positive-unlabeled learning framework to generate a comprehensive list of senescence marker genes in human lungs (termed SenSet) using the largest publicly available single-cell lung dataset, th

SUBMITTER: Euxhen Hasanaj 

PROVIDER: S-SCDT-10_1038-S44318-026-00762-8 | biostudies-other |

REPOSITORIES: biostudies-other