Elucidating the protein interaction network of one of the largest icosahedral capsids in the virosphere

ABSTRACT: Giant viruses challenge traditional boundaries of virology with their large particle sizes, complex genomes, and unique replication strategies. Yet, despite its 750 nm diameter and incorporation of dozens of proteins, the mimivirus virion retains an icosahedral symmetry, a trait often associated with smaller viruses. The functional roles and interactions of most proteins composing such complex icosahedral particles remain elusive. Here, we dissect the spatial and functional organization of mimivirus morphogenesis by integrating bioinformatics, genetics and interactomics. We performed protein clustering using a structure-informed approach, integrating AlphaFold models with sequence information, to classify and functionally annotate the orphan-protein-rich mimivirus proteome. To map the prot

SUBMITTER: Hela Safi 

PROVIDER: S-SCDT-10_1038-S44318-026-00770-8 | biostudies-other |

REPOSITORIES: biostudies-other