Interferon γ selectively promotes survival of alveolar progenitor cells in a human lung organoid model

ABSTRACT: Disease of the lung alveoli is frequently associated with acute or chronic inflammation. At present, there are no effective therapies to support regeneration of the alveolar epithelium, and ongoing inflammation adds an additional layer of complexity to many lung diseases. Here, we describe a primary adult human organoid model for investigating how inflammation shapes alveolar regeneration. Unlike previous models, this system supports long-term expansion of newly identified human-specific alveolar progenitor cells and serum-free differentiation into alveolar type 1 (AT1)-like cells. Using this platform, we find that interferon-gamma (IFN-γ) exerts cytotoxic effects on mature AT1-like cells while promoting survival of alveolar progenitor cells mediated by BIRC3. This unexpected selective pos

SUBMITTER: Antonella, FM Dost 

PROVIDER: S-SCDT-10_1038-S44318-026-00774-4 | biostudies-other |

REPOSITORIES: biostudies-other