Structural insights into bacterial dimethylsulfoniopropionate import by BCCT-family transporters

ABSTRACT: Dimethylsulfoniopropionate (DMSP) is a ubiquitous marine organosulfur compound central to microbial stress responses, chemotaxis, and nutrient cycling. Its catabolism produces dimethylsulfide (DMS), a climate-active gas, and plays a key role in the global sulfur cycle. However, the molecular basis of DMSP import, underpinning its microbial metabolism, remains poorly understood. Here, we identify and characterize the BCCT-family transporter DddT from Psychrobacter sp. D2, a marine gamma-proteobacterium that utilizes DMSP as a carbon source. DddT is essential for DMSP uptake and functions as a Na+-coupled symporter driven by the transmembrane sodium gradient. Using cryo-electron microscopy, we determined DddT structures in multiple conformational states, revealing its Na+-dependent transport

SUBMITTER: Yu-Zhong Zhang 

PROVIDER: S-SCDT-10_1038-S44318-026-00798-W | biostudies-other |

REPOSITORIES: biostudies-other