The oocyte-enriched metabolite serotonin alleviates cellular senescence and aging phenotypes in the mouse

ABSTRACT: Whether metabolites enriched at early developmental stages affect cellular and organismal aging remains unclear. In this study, we comprehensively profiled the metabolic landscape mouse oocytes in comparison to cleavage-stage embryos. Our analysis revealed that oocytes display accumulation of reductive metabolites that diminish following fertilization. Notably, we identified serotonin (5-hydroxytryptamine, 5-HT) as an oocyte-enriched metabolite with protective roles in aging. The underlying mechanisms operate through dual pathways: i) in a canonical pathway serotonin acts via its receptor 5HTR1B to modulate mitochondrial function, and ii) in a non-canonical pathway serotonin promotes serotonylation of HSP90β, which effectively reduces endoplasmic reticulum stress. Overall, our study demons

SUBMITTER: Yuyan Xu 

PROVIDER: S-SCDT-10_1038-S44318-026-00832-X | biostudies-other |

REPOSITORIES: biostudies-other