NDR kinase SAX-1 controls dendrite branch-specific pruning during neuronal remodeling in C. elegans

ABSTRACT: Neuronal remodeling is crucial for proper nervous system development and function. Despite significant advances, the underlying mechanisms that govern this process remain poorly understood. Here, we adapted C. elegans IL2 sensory neurons as a model system to study developmental and organismal stress-associated dendrite remodeling. Upon entering developmental diapause, IL2 dendrites grow a complex dendritic arbor, which is later pruned when reproductive development resumes. We identified unexpected specificity in the pruning process, with distinct genetic requirements to direct branch-specific elimination of secondary, tertiary, and quaternary branches. The serine/threonine kinase SAX-1/NDR promotes elimination of secondary and tertiary, but not quaternary, dendrites. SAX-1 functions with i

SUBMITTER: Paola, V Figueroa Delgado 

PROVIDER: S-SCDT-10_1038-S44318-026-00841-W | biostudies-other |

REPOSITORIES: biostudies-other