Autophagy impairment in the Drosophila mushroom body triggers adaptive presynaptic remodeling across the brain

ABSTRACT: Neural circuits must remain functionally stable while adapting to changing demands and levels of stress. While this balance is thought to rely on plasticity programs integrating molecular and activity-dependent signals, mechanistic models of how such adaptations are orchestrated remain limited. Here, we show that impairment of autophagy in the Drosophila mushroom body (MB) induces brain-wide, post-transcriptional remodeling of presynaptic active zones, characterized by increased expression levels of active zone scaffold proteins, reduced abundance of calcium channel subunits, and elevated levels of Shaker-type potassium channels. This remodeling promotes organismal resilience, as reflected by increased sleep and extended lifespan. Mechanistically, early-life activation of this program is s

SUBMITTER: David Toppe 

PROVIDER: S-SCDT-10_1038-S44318-026-00847-4 | biostudies-other |

REPOSITORIES: biostudies-other