PP2A phosphatase regulates Hippo signalling in dual manner

ABSTRACT: Hippo signalling is an evolutionarily conserved pathway that regulates tissue growth. The FERM domain protein Expanded (Ex) integrates polarity cues to activate the Hippo pathway. Previous work has shown that the apicobasal polarity protein Crumbs can limit Hippo activity by promoting the phosphorylation and degradation of Expanded. Here, we provide evidence that serine/threonine phosphatase, protein phosphatase 2A (PP2A) has a dual role in the regulation of Hippo signalling in Drosphila cell culture and wing discs. We show that PP2AWrd, the PP2A holoenzyme equipped with the Wrd regulatory subunit, counteracts the effects of Crumbs, by dephosphorylating and stabilising Expanded. We demonstrate that the PP2AWrd holoenzyme can increase Hippo signalling activity, in contrast to the previously

SUBMITTER: Aashika Sekar 

PROVIDER: S-SCDT-10_1038-S44318-026-00850-9 | biostudies-other |

REPOSITORIES: biostudies-other