Pho84/GLUT2 are cellular myo-inositol exporters regulated by inositol pyrophosphates

ABSTRACT: Inositol is an essential nutrient for most living organisms, as combinatorial phosphorylation on this cyclic sugar generates key cellular messengers, such as lipid-bound phosphoinositides (PtdInsPs), water-soluble inositol phosphates (InsPs), and high-energy inositol pyrophosphates (PP-InsPs). Although the kinases and phosphatases modifying inositol-derived molecules are well-characterised, the molecular pathways controlling the cellular homeostasis of the inositol backbone and transport carriers remain unclear. Using a combination of LC-MS analysis and a screen based on the inositol-exporting opi1Δ mutant yeast, we here discovered that inositol export is tightly regulated by PP-InsPs and that the high-affinity phosphate transporter Pho84 also acts as an inositol exporter. We further expan

SUBMITTER: Xue, Bessie Su 

PROVIDER: S-SCDT-10_1038-S44318-026-00888-9 | biostudies-other |

REPOSITORIES: biostudies-other