Three-Dimensional Mechanical Cooperativity Optimises Epithelial Wound Healing

ABSTRACT: Epithelial tissues serve as critical physical barriers that protect organs, making their efficient repair essential upon damage. To achieve this, tissues must quickly react, forcing cells to rearrange and accommodate to achieve rapid wound closure. In the Drosophila wing disc, we previously showed how tissue fluidisation accelerated wound healing in 2D. However, the 3D aspect of tissue repair remains poorly understood. Here, we uncover a new mechanism that facilitates tissue repair through changing cell height. We find actomyosin contractile cables at the wound edge connecting the apical and basal cell surfaces, which indent the apical side of the tissue and deform the basement membrane, respectively. To assess the role of the different repair mechanisms, we develop a 3D vertex model allow

SUBMITTER: Shu En Lim 

PROVIDER: S-SCDT-10_1038-S44318-026-00925-7 | biostudies-other |

REPOSITORIES: biostudies-other