Cis-regulatory co-option of a transposon family reinforces cell identity across the immune system

ABSTRACT: Transposable elements (TEs) comprise about half of the human and mouse genomes and contribute to gene regulation during immune responses. However, how TEs acquire cis-regulatory functions during immune cell development remains poorly understood. Here, we analyzed hundreds of datasets profiling chromatin accessibility, gene expression, transcription factor occupancy and DNA-DNA contact across diverse mouse and human immune cell types. We identified two rodent-specific TE subfamilies, ORR1E and ORR1D2 (collectively, ODE) that have diversified after genomic insertion into cell type-specific enhancers across the mouse immune system. Post-insertion mutations in ODE loci generated differential binding sites for lineage-specifying transcription factors. ODEs showed evidence of evolutionary sequen

SUBMITTER: Jason, D Chobirko 

PROVIDER: S-SCDT-10_1038-S44318-026-00938-2 | biostudies-other |

REPOSITORIES: biostudies-other